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Niedre, M.* ; Ntziachristos, V.

Complete angle small animal fluorescence imaging with early-arriving photons.

Conf. Proc. IEEE Eng. Med. Biol. Soc., 6331-6334 (2009)
DOI PMC
Fluorescence mediated tomography allows quantitative, three-dimensional imaging of optical reporter probes in whole animals and is therefore emerging as a powerful molecular imaging tool. The achievable image quality in fluorescence tomography is limited by the high-degree of light scatter in biological tissue. Time-gated detection of early-arriving and therefore minimally-scattered photons transmitted through diffusive tissue is one strategy for minimizing the effects of light scatter. In this work, we performed full-angle tomographic imaging of mice implanted with fluorescent tubes using time-gated detection of early- and later-arriving photons. This was achieved using a femtosecond laser and a high-speed, time-gated intensified CCD imager. We demonstrate that the early-transmitted fluorescent photons allow improved visualization of the fluorescence distribution, even when considering individual projections through the animal. High-fidelity image reconstruction using 72 projections in 5-degree steps using early-arriving photons is also demonstrated.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter optical imaging; optical tomography; fluorescence
Sprache englisch
Veröffentlichungsjahr 2009
HGF-Berichtsjahr 0
ISSN (print) / ISBN 1557-170X
Konferenztitel 31st Annual International Conference of the IEEE EMBS Mineapolis, Minnesota, USA, September 2-6, 2009
Zeitschrift Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Quellenangaben Band: , Heft: , Seiten: 6331-6334 Artikelnummer: , Supplement: ,
Verlag Institute of Electrical and Electronics Engineers (IEEE)
Verlagsort Minneapolis, MN
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-505500-001
PubMed ID 19964155
DOI 10.1109/IEMBS.2009.5333167
Erfassungsdatum 2009-12-31
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