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Rochat, M.K.* ; Ege, M.J.* ; Plabst, D.* ; Steinle, J.* ; Bitter, S.* ; Braun-Fahrländer, C.* ; Dalphin, J.-C.* ; Riedler, J.* ; Roponen, M.* ; Hirvonen, M.R.* ; Büchele, G.* ; Renz, H.* ; Lauener, R.* ; Krauss-Etschmann, S. ; von Mutius, E.* ; PASTURE Study Group (*)

Maternal vitamin D intake during pregnancy increases gene expression of ILT3 and ILT4 in cord blood.

Clin. Exp. Allergy 40, 786-794 (2010)

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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

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Background Recent studies indicate that prenatal vitamin D intake may protect against the development of atopic diseases in young children. Vitamin D has been shown to induce tolerogenic antigen-presenting cells such as dendritic cells. Whether the allergy-protective potential of prenatal vitamin D is mediated through such mechanisms is, however, unknown. Objective To evaluate the association between prenatal vitamin D supplementation and tolerogenic antigen-presenting cells in cord blood (CB) as determined by mRNA measurement of immunoglobulin-like transcripts (ILT)3 and ILT4. Methods A prospective multi-centre birth cohort was established in rural areas of five European countries. Information on maternal exposures including vitamin D intake was collected by questionnaires during pregnancy. The gene expression of ILT3 and ILT4 was analysed by real-time PCR in the CB of 927 children. Maternal vitamin D supplementation was assessed in Finland and France (n=349). Results Maternal vitamin D supplementation during pregnancy was associated with an increase in the gene expression of ILT3 (P=0.012) and ILT4 (P<0.001). This association remained significant for ILT4 (P=0.020) and showed a positive trend for the gene expression of ILT3 (P=0.059) after multivariate analysis controlling for various confounders. Conclusions Vitamin D supplementation during pregnancy may increase the mRNA levels of ILT3 and ILT4 in CB. This finding may point towards an early induction of tolerogenic immune responses by maternal vitamin D intake.

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