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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Further delineation of the association signal on chromosome 5 from the first whole genome association study in Parkinson's disease.
Neurobiol. Aging 30, 1706-1709 (2009)
A recently published whole genome association study showed the involvement of 13 SNPs in the pathogenesis of Parkinson disease (PD). We performed a replication study to assess their involvement in our sporadic cohort consisting of 663 cases and 1002 controls ascertained from Germany. One of the previously reported SNP, rs7723605, showed evidence of association (p value 0.04) in our sample. We further refined the signal by genotyping additional 22 SNPs around SNP rs7723605. Our refinement analysis, however, did not provide evidence for association in our sample after adjusting for multiple testing by permutation procedure. In conclusion, our study did not lend support to the finding that the reported SNPs are directly influencing the susceptibility to sporadic form of PD at least in our population.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
5.959
1.590
1
2
Anmerkungen
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Parkinson disease; Whole genome association; Linkage disequilibrium (LD)
Sprache
englisch
Veröffentlichungsjahr
2009
HGF-Berichtsjahr
2009
ISSN (print) / ISBN
0197-4580
e-ISSN
1558-1497
Zeitschrift
Neurobiology of Aging
Quellenangaben
Band: 30,
Heft: 10,
Seiten: 1706-1709
Verlag
Elsevier
Verlagsort
New York, NY [u.a.]
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Human Genetics (IHG)
Institute of Epidemiology (EPI)
Institute of Epidemiology (EPI)
POF Topic(s)
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30503 - Chronic Diseases of the Lung and Allergies
30503 - Chronic Diseases of the Lung and Allergies
Forschungsfeld(er)
Genetics and Epidemiology
PSP-Element(e)
G-500700-001
G-503900-003
G-503900-003
PubMed ID
18280617
Scopus ID
69249217990
Erfassungsdatum
2009-12-31