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Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.
COP9 signalosome controls the Carma1-Bcl10-Malt1 complex upon T-cell stimulation.
EMBO Rep. 10, 642-648 (2009)
The Carma1-Bcl10-Malt1 (CBM) complex connects T-cell receptor (TCR) signalling to the canonical I kappa B kinase (IKK)/NF (nuclear factor)-kappa B pathway. Earlier studies have indicated that the COP9 signalosome (CSN), a pleiotropic regulator of the ubiquitin/26S proteasome system, controls antigen responses in T cells. The CSN is required for the degradation of the NF-kappa B inhibitor I kappa B alpha, but other molecular targets involved in T-cell signalling remained elusive. Here, we identify the CSN subunit 5 (CSN5) as a new interactor of Malt1 and Carma1. T-cell activation triggers the recruitment of the CSN to the CBM complex, and CSN downregulation impairs TCR-induced IKK activation. Furthermore, the CSN is required for maintaining the stability of Bcl10 in response to T-cell activation. Taken together, our data provide evidence for a functional link between the evolutionarily conserved CSN and the adaptive immunoregulatory CBM complex in T cells.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
7.099
1.040
20
26
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
COP9 signalosome; signalling; T-cell activation; nf-kappa-b; ubiquitin ligases; activation; bcl10; cycle; regulator; csn; phosphorylation; degradation; subcomplex
Sprache
englisch
Veröffentlichungsjahr
2009
HGF-Berichtsjahr
2009
ISSN (print) / ISBN
1469-221X
e-ISSN
1469-3178
Zeitschrift
EMBO Reports
Quellenangaben
Band: 10,
Heft: 6,
Seiten: 642-648
Verlag
EMBO Press
Begutachtungsstatus
Peer reviewed
Institut(e)
Research Unit Signaling and Translation (SAT)
POF Topic(s)
30203 - Molecular Targets and Therapies
Forschungsfeld(er)
Enabling and Novel Technologies
PSP-Element(e)
G-509800-002
PubMed ID
19444310
Scopus ID
67349196860
Erfassungsdatum
2009-07-09