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Schlosser, E.* ; Otero, C.* ; Wuensch, C.* ; Kessler, B.* ; Edelmann, M.* ; Brunisholz, R.* ; Drexler, I. ; Legler, D.F.* ; Groettrup, M.

A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins.

EMBO Rep. 8, 945-951 (2007)
DOI PMC
Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.
Proteins bearing an endoplasmic reticulum (ER) leader are inserted into the ER followed by cleavage of the signal peptide. Major histocompatibility complex class I-restricted T-cell epitopes can be generated from these proteins by the proteasome after retrotranslocation into the cytosol. Here, we show that an HLA-A*0201-restricted epitope from prostate stem cell antigen contains the cleavage site of the ER signal peptidase. The resulting cleavage products fail to bind to HLA-A*0201 and are not recognized by T lymphocytes. As processing of prostate stem cell antigen by signal peptidase occurs immediately after co-translational insertion, the epitope must be processed from polypeptides that have never reached the ER. The processing of this epitope depends on the proteasome and the transporter associated with antigen processing and shows a novel pathway of class I processing that relies on the failure of ER-targeted proteins to reach their target compartment.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter endoplasmic reticulum; antigen processing; Major histocompatibility complex class I; signal peptidase; cytoxic T lymphocytes
Sprache englisch
Veröffentlichungsjahr 2007
HGF-Berichtsjahr 2007
ISSN (print) / ISBN 1469-221X
e-ISSN 1469-3178
Zeitschrift EMBO Reports
Quellenangaben Band: 8, Heft: 10, Seiten: 945-951 Artikelnummer: , Supplement: ,
Verlag EMBO Press
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Virology (VIRO)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Immune Response and Infection
PSP-Element(e) G-502700-002
PubMed ID 17404459
DOI 10.1038/sj.embor.7401065
WOS ID 000249884600015
Scopus ID 34848897897
Erfassungsdatum 2007-11-09
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