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Markus, M.R.P.* ; Stritzke, J.* ; Lieb, W.* ; Mayer, B.* ; Luchner, A.* ; Döring, A. ; Keil, U.* ; Hense, H.-W.* ; Schunkert, H.*

Implications of persistent prehypertension for ageing-related changes in left ventricular geometry and function: The Mokay werONICA/KORA Augsburg study.

J. Hypertens. 26, 2040-2049 (2008)

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Background: It is unclear whether persistent prehypertension causes structural or functional alterations of the heart. Methods: We examined echocardiographic data of 1005 adults from a population-based survey at baseline in 1994/1995 and at follow-up in 2004/2005. We compared individuals who had either persistently normal (< 120 mmHg systolic and <80 mmHg diastolic, n = 142) or prehypertensive blood pressure (120-139 mmHg or 80-89 mmHg, n = 119) at both examinations using multivariate regression modeling. Results: Over 10 years, left ventricular end-diastolic diameters were stable and did not differ between the two groups. However, the prehypertensive blood pressure group displayed more pronounced ageing-related increases of left ventricular wall thickness (+4.7 versus +11.9%, P < 0.001) and left ventricular mass (+8.6 versus +15.7%, P = 0.006). Prehypertension was associated with a raised incidence of left ventricular concentric remodeling (adjusted odds ratio 10.7, 95% confidence interval 2.82-40.4) and left ventricular hypertrophy (adjusted odds ratio 5.33, 1.58-17.9). The ratio of early and late diastolic peak transmitral flow velocities (E/A) decreased by 7.7% in the normal blood pressure versus 15.7% in the prehypertensive blood pressure group (P=0.003) and at follow-up the ratio of early diastolic peak transmitral flow and early diastolic peak myocardial relaxation velocities (E/EM) was higher (9.1 versus 8.5, P=0.031) and left atrial size was larger (36.5 versus 35.3 mm, P=0.024) in the prehypertensive blood pressure group. Finally, the adjusted odds ratio for incident diastolic dysfunction was 2.52 (1.01-6.31) for the prehypertensive blood pressure group. Conclusions: Persistent prehypertension accelerates the development of hypertrophy and diastolic dysfunction of the heart.

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