PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Libert, C.* ; Wielockx, B.* ; Grijalba, B.* ; van Molle, W.* ; Kremmer, E. ; Colten, H.R.* ; Fiers, W.* ; Brouckaert, P.*

The role of complement activation in tumour necrosis factor-induced lethal hepatitis.

Cytokine 11, 617-625 (1999)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Injection of tumour necrosis factor (TNF) in animals causes severe liver cell toxicity, especially when D-(+)-galactosamine (GalN) is co-administered. After challenge with TNF/GalN, serum complement activity (CH50 and APCH50) decreased dramatically, suggesting strong activation of both the classical and the alternative pathways. TNF or GalN alone had no such effect. A cleavage product of complement protein C3 [C3(b)] was deposited on the surface of hepatocytes of TNF/GalN-treated mice. Intravenous administration of cobra venom factor (CVF), which depletes complement, inhibited the development of hepatitis. However, CVF pretreatment also protected C3-deficient mice. Pretreatment of mice with a C1q-depleting antibody did not prevent TNF/GalN lethality, although the anti-C1q antibody had depleted plasma C1q. Factor B-deficient and C3-deficient mice, generated by gene targeting, proved to be as sensitive to TNF/GalN as control mice. Furthermore, induction of lethal shock by platelet-activating factor, an important mediator in TNF-induced hepatic failure, was not reduced in C3-deficient mice. These data indicate that complement, although activated, plays no major role in the generation of acute lethal hepatic failure in this model and that CVF-induced protection is independent of complement depletion.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
0.000
0.000
11
12
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter complement hepatitis knockout mice shock tumour necrosis factor
Sprache englisch
Veröffentlichungsjahr 1999
HGF-Berichtsjahr 0
ISSN (print) / ISBN 1043-4666
e-ISSN 1096-0023
Zeitschrift Cytokine
Quellenangaben Band: 11, Heft: 8, Seiten: 617-625 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Oxford [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Molecular Immunology (IMI)
DOI 10.1006/cyto.1998.0462
Erfassungsdatum 1999-12-31
[➜Korrektur melden]