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Holler, E. ; Roncarolo, M.G.* ; Hintermeier-Knabe, R.* ; Eissner, G. ; Ertl, B.* ; Schulz, U.* ; Knabe, H. ; Kolb, H.-J. ; Andreesen, R.* ; Wilmanns, W.*

Prognostic significance of increased IL-10 production in patients prior to allogenic bone marrow transplantation.

Bone Marrow Transplant. 25, 237-241 (2000)

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IL-10 is a potent immunosuppressant which inhibits allo-antigen-specific T cell responses. In addition, IL-10 is a strong endogenous anti-inflammatory cytokine. To investigate the role of IL-10 in the induction of acute GVHD following allogeneic bone marrow transplantation (BMT) we performed a prospective study on spontaneous IL-10 production by peripheral blood mononuclear cells (PBMNC) in 84 patients admitted for allogeneic BMT. High spontaneous IL-10 production by PBMNC at the time of admission and prior to any preparative treatment correlated with a subsequent low incidence of GVHD and transplant-related mortality (8%), as compared to patients with low or intermediate IL-10 production (50%, P < 0.01). Our data demonstrate the prognostic significance of increased IL-10 production in BMT patients and suggest a major role of IL-10 in maintaining immunobalance in the setting of allogeneic BMT.

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