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Volumetric tomography of fluorescent proteins through small animals in vivo.
Proc. Natl. Acad. Sci. U.S.A. 102, 18252-18257 (2005)
Volumetric detection and accurate quantification of fluorescent proteins in entire animals would greatly enhance our ability to monitor biological processes in vivo. Here we present a quantitative tomographic technique for visualization of superficial and deep-seated (>2-3 mm) fluorescent protein activity in vivo. We demonstrate noninvasive imaging of lung tumor progression in a murine model, as well as imaging of gene delivery using a herpes virus vector. This technology can significantly improve imaging capacity over the current state of the art and should find wide in vivo imaging applications in drug discovery, immunology, and cancer research.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Sprache
englisch
Veröffentlichungsjahr
2005
HGF-Berichtsjahr
0
ISSN (print) / ISBN
0027-8424
e-ISSN
1091-6490
Quellenangaben
Band: 102,
Heft: 51,
Seiten: 18252-18257
Verlag
National Academy of Sciences
Begutachtungsstatus
Peer reviewed
PubMed ID
16344470
Erfassungsdatum
2005-12-31