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Höck, J.* ; Weinmann, L.* ; Ender, C.* ; Rüdel, S.* ; Kremmer, E. ; Raabe, M.* ; Urlaub, H.* ; Meister, G.*

Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.

EMBO Rep. 8, 1052-1060 (2007)

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Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.

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Members of the Argonaute (Ago) protein family associate with small RNAs and have important roles in RNA silencing. Here, we analysed Ago1- and Ago2-containing protein complexes in human cells. Separation of Ago-associated messenger ribonucleoproteins (mRNPs) showed that Ago1 and Ago2 reside in three complexes with distinct Dicer and RNA-induced silencing complex activities. A comprehensive proteomic analysis of Ago-containing mRNPs identified a large number of proteins involved in RNA metabolism. By using co-immunoprecipitation experiments followed by RNase treatment, we biochemically mapped interactions within Ago mRNPs. Using reporter assays and knockdown experiments, we showed that the putative RNA-binding protein RBM4 is required for microRNA-guided gene regulation.

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