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Vogel, K.U. ; Edelmann, S.L. ; Jeltsch, K. ; Bertossi, A.* ; Heger, K.* ; Heinz, G.A. ; Zöller, J. ; Warth, S.C. ; Hoefig, K.P. ; Lohs, C. ; Neff, F. ; Kremmer, E. ; Schick, J. ; Repsilber, D.* ; Geerlof, A. ; Blum, H.* ; Wurst, W. ; Heikenwälder, M. ; Schmidt-Supprian, M.* ; Heissmeyer, V.

Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation.

Immunity 38, 655-668 (2013)
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The Roquin-1 protein binds to messenger RNAs (mRNAs) and regulates gene expression posttranscriptionally. A single point mutation in Roquin-1, but not gene ablation, increases follicular helper T (Tfh) cell numbers and causes lupus-like autoimmune disease in mice. In T cells, we did not identify a unique role for the much lower expressed paralog Roquin-2. However, combined ablation of both genes induced accumulation of T cells with an effector and follicular helper phenotype. We showed that Roquin-1 and Roquin-2 proteins redundantly repressed the mRNA of inducible costimulator (Icos) and identified the Ox40 costimulatory receptor as another shared mRNA target. Combined acute deletion increased Ox40 signaling, as well as Irf4 expression, and imposed Tfh differentiation on CD4+ T cells. These data imply that both proteins maintain tolerance by preventing inappropriate T cell activation and Tfh cell differentiation, and that Roquin-2 compensates in the absence of Roquin-1, but not in the presence of its mutated form.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Transcription Factor Irf4; B-cells; Kappa-b; Phosphoinositide 3-kinase; Systemic Autoimmunity; Expression; Protein; Generation; Leads; Bcl6
Sprache englisch
Veröffentlichungsjahr 2013
HGF-Berichtsjahr 2013
ISSN (print) / ISBN 1074-7613
e-ISSN 1097-4180
Zeitschrift Immunity
Quellenangaben Band: 38, Heft: 4, Seiten: 655-668 Artikelnummer: , Supplement: ,
Verlag Cell Press
Verlagsort Cambridge, Mass.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Molecular Immunology (IMI)
Institute of Virology (VIRO)
Institute of Pathology (PATH)
Institute of Developmental Genetics (IDG)
Institute of Structural Biology (STB)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30204 - Cell Programming and Repair
30203 - Molecular Targets and Therapies
Forschungsfeld(er) Immune Response and Infection
Enabling and Novel Technologies
Genetics and Epidemiology
PSP-Element(e) G-501792-001
G-501793-001
G-551600-001
G-500300-001
G-500500-001
G-503000-003
G-520600-001
PubMed ID 23583643
DOI 10.1016/j.immuni.2012.12.004
WOS ID WOS:000330942100009
Scopus ID 84876781274
Erfassungsdatum 2013-04-12
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