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Hapfelmeier, S.* ; Lawson, M.A.* ; Slack, E.* ; Kirundi, J.K.* ; Stoel, M.* ; Heikenwälder, M.* ; Cahenzli, J.* ; Velykoredko, Y.* ; Balmer, M.L.* ; Endt, K.* ; Geuking, M.B.* ; Curtiss, R.* ; McCoy, K.D.* ; Macpherson, A.J.*

Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses.

Science 328, 1705-1709 (2010)

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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

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The lower intestine of adult mammals is densely colonized with nonpathogenic (commensal) microbes. Gut bacteria induce protective immune responses, which ensure host-microbial mutualism. The continuous presence of commensal intestinal bacteria has made it difficult to study mucosal immune dynamics. Here, we report a reversible germ-free colonization system in mice that is independent of diet or antibiotic manipulation. A slow (more than 14 days) onset of a long-lived (half-life over 16 weeks), highly specific anticommensal immunoglobulin A (IgA) response in germ-free mice was observed. Ongoing commensal exposure in colonized mice rapidly abrogated this response. Sequential doses lacked a classical prime-boost effect seen in systemic vaccination, but specific IgA induction occurred as a stepwise response to current bacterial exposure, such that the antibody repertoire matched the existing commensal content.

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