PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Sirko, S. ; Behrendt, G.* ; Johansson, P.A. ; Tripathi, P. ; Costa, M.R. ; Bek, S. ; Heinrich, C.* ; Tiedt, S.* ; Colak, D. ; Dichgans, M.* ; Fischer, I.R.* ; Plesnila, N.* ; Staufenbiel, M.* ; Haass, C.* ; Snapyan, M.* ; Saghatelyan, A.* ; Tsai, L.H.* ; Fischer, A.* ; Grobe, K.* ; Dimou, L. ; Götz, M.

Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog.

Cell Stem Cell 12, 426-439 (2013)
Verlagsversion Volltext DOI PMC
Closed
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
As a result of brain injury, astrocytes become activated and start to proliferate in the vicinity of the injury site. Recently, we had demonstrated that these reactive astrocytes, or glia, can form self-renewing and multipotent neurospheres in vitro. In the present study, we demonstrate that it is only invasive injury, such as stab wounding or cerebral ischemia, and not noninvasive injury conditions, such as chronic amyloidosis or induced neuronal death, that can elicit this increase in plasticity. Furthermore, we find that Sonic hedgehog (SHH) is the signal that acts directly on the astrocytes and is necessary and sufficient to elicit the stem cell response both in vitro and in vivo. These findings provide a molecular basis for how cells with neural stem cell lineage emerge at sites of brain injury and imply that the high levels of SHH known to enter the brain from extraneural sources after invasive injury can trigger this response.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
25.315
3.496
227
218
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Neural Stem/progenitor Cells; Focal Cerebral-ischemia; In-vitro; Spinal-cord; Astrocyte Proliferation; Zebrafish Telencephalon; Subventricular Zone; Alzheimers-disease; Transgenic Mice; Self-renewal
Sprache englisch
Veröffentlichungsjahr 2013
HGF-Berichtsjahr 2013
ISSN (print) / ISBN 1934-5909
e-ISSN 1875-9777
Zeitschrift Cell Stem Cell
Quellenangaben Band: 12, Heft: 4, Seiten: 426-439 Artikelnummer: , Supplement: ,
Verlag Cell Press
Verlagsort Cambridge, Mass.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Stem Cell Research (ISF)
POF Topic(s) 30204 - Cell Programming and Repair
Forschungsfeld(er) Stem Cell and Neuroscience
PSP-Element(e) G-500800-001
PubMed ID 23561443
DOI 10.1016/j.stem.2013.01.019
WOS ID WOS:000329569500010
Scopus ID 84875946599
Erfassungsdatum 2013-05-22
[➜Korrektur melden]