PuSH - Publikationsserver des Helmholtz Zentrums München: Oral disinfectants inhibit protein-protein interactions mediated by the anti-apoptotic protein Bcl-x<sub>L</sub> and induce apoptosis in human oral tumor cells.

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Gräber, M.* ; Hell, M.* ; Grost, C.* ; Friberg, A. ; Sperl, B.* ; Sattler, M. ; Berg, T.*

Oral disinfectants inhibit protein-protein interactions mediated by the anti-apoptotic protein Bcl-x_L and induce apoptosis in human oral tumor cells.

Angew. Chem.-Int. Edit. 52, 4487-4491 (2013)

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Chlorhexidine and alexidine have long been used as oral disinfectants by humans. Both compounds inhibit protein-protein interactions mediated by the anti-apoptotic protein Bcl-xL at physiologically relevant concentrations and induce apoptosis in a series of tumor cell lines derived from the tongue and pharynx (see picture). Inhibition of protein-protein interactions is a potential mode of action of drugs in current human use. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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PuSH - Publikationsserver des Helmholtz Zentrums München

Oral disinfectants inhibit protein-protein interactions mediated by the anti-apoptotic protein Bcl-xL and induce apoptosis in human oral tumor cells.

Oral disinfectants inhibit protein-protein interactions mediated by the anti-apoptotic protein Bcl-x_L and induce apoptosis in human oral tumor cells.