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Glatz, J.* ; Varga, J.* ; Garcia-Allende, P. ; Koch, M. ; Greten, F.R.* ; Ntziachristos, V.

Concurrent video-rate color and near-infrared fluorescence laparoscopy.

J. Biomed. Opt. 18:101302 (2013)
Verlagsversion Volltext DOI PMC
Open Access Gold
The visual identification and demarcation of tumors and tumor margins remains challenging due to the low optical contrast of cancer cells over surrounding tissues. Fluorescence molecular imaging was recently considered clinically for improving cancer detection during open surgery. We present herein a next step in the development of fluorescence molecular guidance by describing a novel video-rate imaging laparoscope capable of concurrently recording color and near-infrared fluorescence images and video. Video-rate operation is based on graphics processing unit-based image processing. We examine the optical characteristics of the system developed and provide performance metrics related to intra-operative endoscopic guidance, showcased on phantoms and endoscopic color and fluorescence molecular imaging of tumors in a mouse model of the human disease.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter cancer; laparoscopy; endoscopy; near-infrared imaging; optical imaging; intraoperative imaging; fluorescence imaging; Mouse Models ; Cancer ; Colonoscopy ; Inflammation ; Tumors ; Diagnosis ; Oncology ; Polyp ; Gene ; Mice
Sprache englisch
Veröffentlichungsjahr 2013
HGF-Berichtsjahr 2013
ISSN (print) / ISBN 1083-3668
e-ISSN 1560-2281
Zeitschrift Journal of Biomedical Optics
Quellenangaben Band: 18, Heft: 10, Seiten: , Artikelnummer: 101302 Supplement: ,
Verlag SPIE
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-505500-001
PubMed ID 23797876
DOI 10.1117/1.JBO.18.10.101302
WOS ID WOS:000326563000008
Scopus ID 84886782746
Erfassungsdatum 2013-06-11
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