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Dräxl, S. ; Müller, J. ; Li, W.B. ; Michalke, B. ; Scherb, H. ; Hense, B.A. ; Tschiersch, J. ; Kanter, U. ; Schäffner, A.

Caesium accumulation in yeast and plants is selectively repressed by loss of the SNARE Sec22p/SEC22.

Nat. Commun. 4:2092 (2013)
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The non-essential cation caesium (Cs+) is assimilated by all organisms. Thus, anthropogenically released radiocaesium is of concern to agriculture. Cs+ accumulates owing to its chemical similarity to the potassium ion (K+). The apparent lack of a Cs+-specific uptake mechanism has obstructed attempts to manipulate Cs+ accumulation without causing pleiotropic effects. Here we show that the SNARE protein Sec22p/SEC22 specifically impacts Cs+ accumulation in yeast and in plants. Loss of Saccharomyces cerevisiae Sec22p does not affect K+ homeostasis, yet halves Cs+ concentration compared with the wild type. Mathematical modelling of the uptake time course predicts a compromised vacuolar Cs+ deposition in sec22Δ. Biochemical fractionation confirms this and indicates a new feature of Sec22p in enhancing non-selective cation deposition. A developmentally controlled loss-of-function mutant of the orthologous Arabidopsis thaliana SEC22 phenocopies the reduced Cs+ uptake without affecting plant growth. This finding provides a new strategy to reduce radiocaesium entry into the food chain.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Plasma-membrane Atpase ; Saccharomyces-cerevisiae ; Arabidopsis-thaliana ; Vacuolar Membrane ; Strontium Accumulation ; Alpha-mannosidase ; Escherichia-coli ; K+ Uptake ; V-atpase ; Transport
Sprache englisch
Veröffentlichungsjahr 2013
HGF-Berichtsjahr 2013
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 4, Heft: , Seiten: , Artikelnummer: 2092 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Environmental Simulation (EUS)
Institute of Computational Biology (ICB)
Research Unit Medical Radiation Physics and Diagnostics (AMSD)
Research Unit BioGeoChemistry and Analytics (BGC)
Institute of Radiation Protection (ISS)
POF Topic(s) 30202 - Environmental Health
30205 - Bioengineering and Digital Health
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Environmental Sciences
Enabling and Novel Technologies
Radiation Sciences
PSP-Element(e) G-504900-002
G-503800-001
G-503600-001
G-504800-002
G-501100-002
DOI 10.1038/ncomms3092
WOS ID WOS:000323714900002
Scopus ID 84880131179
Erfassungsdatum 2013-07-02
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