PuSH - Publikationsserver des Helmholtz Zentrums München: Posttraumatic stress disorder and not depression is associated with shorter leukocyte telomere length: Findings from 3,000 participants in the population-based KORA F4 study.

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Ladwig, K.-H. ; Brockhaus, A.C. ; Baumert, J.J. ; Lukaschek, K. ; Emeny, R.T. ; Kruse, J.* ; Codd, V.* ; Häfner, S. ; Albrecht, E. ; Illig, T. ; Samani, N.J.* ; Wichmann, H.-E. ; Gieger, C. ; Peters, A.

Posttraumatic stress disorder and not depression is associated with shorter leukocyte telomere length: Findings from 3,000 participants in the population-based KORA F4 study.

PLoS ONE 8:e64762 (2013)

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BACKGROUND: A link between severe mental stress and shorter telomere length (TL) has been suggested. We analysed the impact of Posttraumatic Stress Disorder (PTSD) on TL in the general population and postulated a dose-dependent TL association in subjects suffering from partial PTSD compared to full PTSD. METHODS: Data are derived from the population-based KORA F4 study (2006-2008), located in southern Germany including 3,000 individuals (1,449 men and 1,551 women) with valid and complete TL data. Leukocyte TL was measured using a quantitative PCR-based technique. PTSD was assessed in a structured interview and by applying the Posttraumatic Diagnostic Scale (PDS) and the Impact of Event Scale (IES). A total of 262 (8.7%) subjects qualified for having partial PTSD and 51 (1.7%) for full PTSD. To assess the association of PTSD with the average TL, linear regression analyses with adjustments for potential confounding factors were performed. RESULTS: The multiple model revealed a significant association between partial PTSD and TL (beta = -0.051, p = 0.009) as well as between full PTSD and shorter TL (beta = -0.103, p = 0.014) indicating shorter TL on average for partial and full PTSD. An additional adjustment for depression and depressed mood/exhaustion gave comparable beta estimations. CONCLUSIONS: Participants with partial and full PTSD had significantly shorter leukocyte TL than participants without PTSD. The dose-dependent variation in TL of subjects with partial and full PTSD exceeded the chronological age effect, and was equivalent to an estimated 5 years in partial and 10 years in full PTSD of premature aging.

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