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Lopez del Amo, J.M. ; Schneider, D.* ; Loquet, A.* ; Lange, A.* ; Reif, B.

Cryogenic solid state NMR studies of fibrils of the Alzheimer's disease amyloid-β peptide: Perspectives for DNP.

J. Biomol. NMR 56, 359-363 (2013)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Dynamic Nuclear Polarization solid-state NMR holds the potential to enable a dramatic increase in sensitivity by exploiting the large magnetic moment of the electron. However, applications to biological solids are hampered in uniformly isotopically enriched biomacromolecules due to line broadening which yields a limited spectral resolution at cryogenic temperatures. We show here that high magnetic fields allow to overcome the broadening of resonance lines often experienced at liquid nitrogen temperatures. For a fibril sample of the Alzheimer's disease β-amyloid peptide, we find similar line widths at low temperature and at room temperature. The presented results open new perspectives for structural investigations in the solid-state.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Dynamic nuclear polarization (DNP); Magic angle spinning (MAS); Solid-state; NMR high magnetic fields; Alzheimer’s β-amyloid fibrils; Dynamic-nuclear-polarization ; Spectroscopy ; Transition ; Proteins
Sprache englisch
Veröffentlichungsjahr 2013
HGF-Berichtsjahr 2013
ISSN (print) / ISBN 0925-2738
e-ISSN 1573-5001
Zeitschrift Journal of Biomolecular NMR
Quellenangaben Band: 56, Heft: 4, Seiten: 359-363 Artikelnummer: , Supplement: ,
Verlag Springer
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Structural Biology (STB)
POF Topic(s) 30203 - Molecular Targets and Therapies
30505 - New Technologies for Biomedical Discoveries
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-503090-001
G-503000-004
PubMed ID 23793606
DOI 10.1007/s10858-013-9755-5
WOS ID WOS:000323661800007
Scopus ID 84883449183
Erfassungsdatum 2013-07-31
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