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Wredenberg, A.* ; Lagouge, M.* ; Bratic, A.* ; Metodiev, M.D.* ; Spåhr, H.* ; Mourier, A.* ; Freyer, C.* ; Ruzzenente, B.* ; Tain, L.* ; Grönke, S.* ; Baggio, F.* ; Kukat, C.* ; Kremmer, E. ; Wibom, R.* ; Polosa, P.L.* ; Habermann, B.* ; Partridge, L.* ; Park, C.B.* ; Larsson, N.G.*

MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals.

PLoS Genet. 9:e1003178 (2013)
Verlagsversion Volltext DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Regulation of mitochondrial DNA (mtDNA) expression is critical for the control of oxidative phosphorylation in response to physiological demand, and this regulation is often impaired in disease and aging. We have previously shown that mitochondrial transcription termination factor 3 (MTERF3) is a key regulator that represses mtDNA transcription in the mouse, but its molecular mode of action has remained elusive. Based on the hypothesis that key regulatory mechanisms for mtDNA expression are conserved in metazoans, we analyzed Mterf3 knockout and knockdown flies. We demonstrate here that decreased expression of MTERF3 not only leads to activation of mtDNA transcription, but also impairs assembly of the large mitochondrial ribosomal subunit. This novel function of MTERF3 in mitochondrial ribosomal biogenesis is conserved in the mouse, thus we identify a novel and unexpected role for MTERF3 in coordinating the crosstalk between transcription and translation for the regulation of mammalian mtDNA gene expression.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2013
HGF-Berichtsjahr 2013
ISSN (print) / ISBN 1553-7390
e-ISSN 1553-7404
Zeitschrift PLoS Genetics
Quellenangaben Band: 9, Heft: 1, Seiten: , Artikelnummer: e1003178 Supplement: ,
Verlag Public Library of Science (PLoS)
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Molecular Immunology (IMI)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Immune Response and Infection
PSP-Element(e) G-501793-001
PubMed ID 23300484
DOI 10.1371/journal.pgen.1003178
Scopus ID 84873489199
Erfassungsdatum 2013-08-01
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