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Montrone, C. ; Kokkaliaris, K.D. ; Loeffler, D. ; Lechner, M. ; Kastenmüller, G. ; Schroeder, T. ; Ruepp, A.

HSC-Explorer: A curated database for hematopoietic stem cells.

PLoS ONE 8:e70348 (2013)
Verlagsversion Volltext DOI
Open Access Gold
Creative Commons Lizenzvertrag
HSC-Explorer (http://mips.helmholtz-muenchen.de/HSC/) is a publicly available, integrative database containing detailed information about the early steps of hematopoiesis. The resource aims at providing fast and easy access to relevant information, in particular to the complex network of interacting cell types and molecules, from the wealth of publications in the field through visualization interfaces. It provides structured information on more than 7000 experimentally validated interactions between molecules, bioprocesses and environmental factors. Information is manually derived by critical reading of the scientific literature from expert annotators. Hematopoiesis-relevant interactions are accompanied with context information such as model organisms and experimental methods for enabling assessment of reliability and relevance of experimental results. Usage of established vocabularies facilitates downstream bioinformatics applications and to convert the results into complex networks. Several predefined datasets (Selected topics) offer insights into stem cell behavior, the stem cell niche and signaling processes supporting hematopoietic stem cell maintenance. HSC-Explorer provides a versatile web-based resource for scientists entering the field of hematopoiesis enabling users to inspect the associated biological processes through interactive graphical presentation.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Bone-marrow Niche ; Self-renewal Capacity ; Progenitor Cells ; In-vivo ; Differentiation ; Representation ; Reconstitution ; Quiescence ; Networks ; Resource
Sprache englisch
Veröffentlichungsjahr 2013
HGF-Berichtsjahr 2013
ISSN (print) / ISBN 1932-6203
Zeitschrift PLoS ONE
Quellenangaben Band: 8, Heft: 7, Seiten: , Artikelnummer: e70348 Supplement: ,
Verlag Public Library of Science (PLoS)
Verlagsort Lawrence, Kan.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Bioinformatics and Systems Biology (IBIS)
Research Unit Stem Cell Dynamics (SCD)
POF Topic(s) 30505 - New Technologies for Biomedical Discoveries
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Enabling and Novel Technologies
Stem Cell and Neuroscience
PSP-Element(e) G-503700-001
G-501200-001
DOI 10.1371/journal.pone.0070348
WOS ID WOS:000323114200077
Scopus ID 84880841472
Erfassungsdatum 2013-08-08
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