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He, Y. ; Fekete, A. ; Chen, G.N.* ; Harir, M. ; Zhang, L.* ; Tong, P.* ; Schmitt-Kopplin, P.

Analytical approaches for an important shellfish poisoning agent: Domoic acid.

J. Agric. Food Chem. 58, 11525-11533 (2010)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Domoic acid (DA), a neurotoxic amino acid produced by some strains of phytoplankton, is responsible for the human toxic syndrome amnesic shellfish poisoning. This exocitotoxin results in neuronal degeneration and necrosis in specific regions of the hippocampus. Because DA accumulates mostly in shellfish, causing outbreaks in different countries, screening for DA has been carried out with various assays. Although bioassays and immunoassays have been developed, several liquid chromatographic methods for the determination of DA in different matrices such as shellfish, algae, or seawater have been reported. Additionally, other alternative methods such as capillary electrophoresis and capillary electrochromatography have been described. This paper summaries the toxicology, the chemistry, and the developed determination methods of DA.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Domoic acid; shellfish poisoning; determination; sample preparation; HPLC; CE; CEC
Sprache englisch
Veröffentlichungsjahr 2010
HGF-Berichtsjahr 2010
ISSN (print) / ISBN 0021-8561
e-ISSN 1520-5118
Zeitschrift Journal of Agricultural and Food Chemistry
Quellenangaben Band: 58, Heft: 22, Seiten: 11525-11533 Artikelnummer: , Supplement: ,
Verlag American Chemical Society (ACS)
Verlagsort Washington, DC
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Ecological Chemistry (IOEC)
PSP-Element(e) G-505100-007
G-505190-001
PubMed ID 20964434
DOI 10.1021/jf1031789
Scopus ID 78649233647
Erfassungsdatum 2010-12-31
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