PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
MacIntyre, E.A. ; Carlsten, C.* ; Macnutt, M.* ; Fuertes, E. ; Melén, E.* ; Tiesler, C.M. ; Gehring, U.* ; Krämer, U.* ; Klümper, C.* ; Kerkhof, M.* ; Chan-Yeung, M.* ; Kozyrskyj, A.L.* ; Berdel, D.* ; Bauer, C.P.* ; Herbarth, O.* ; Bauer, M. ; Schaaf, B.* ; Koletzko, S.* ; Pershagen, G.* ; Brunekreef, B.* ; Heinrich, J. ; Brauer, M.*

Traffic, asthma and genetics: Combining international birth cohort data to examine genetics as a mediator of traffic-related air pollution's impact on childhood asthma.

Eur. J. Epidemiol. 28, 597-606 (2013)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Associations between traffic-related air pollution and incident childhood asthma can be strengthened by analysis of gene-environment interactions, but studies have typically been limited by lack of study power. We combined data from six birth cohorts on: asthma, eczema and allergic rhinitis to 7/8 years, and candidate genes. Individual-level assessment of traffic-related air pollution exposure was estimated using land use regression or dispersion modeling. A total of 11,760 children were included in the Traffic, Asthma and Genetics (TAG) Study; 6.3 % reported physician-diagnosed asthma at school-age, 16.0 % had asthma at anytime during childhood, 14.1 % had allergic rhinitis at school-age, 10.0 % had eczema at school-age and 33.1 % were sensitized to any allergen. For GSTP1 rs1138272, the prevalence of heterozygosity was 16 % (range amongst individual cohorts, 11-17 %) and homozygosity for the minor allele was 1 % (0-2 %). For GSTP1 rs1695, the prevalence of heterozygosity was 45 % (40-48 %) and homozygosity for the minor allele, 12 % (10-12 %). For TNF rs1800629, the prevalence of heterozygosity was 29 % (25-32 %) and homozygosity for the minor allele, 3 % (1-3 %). TAG comprises a rich database, the largest of its kind, for investigating the effect of genotype on the association between air pollution and childhood allergic disease.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
5.118
1.521
15
15
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Air Pollution ; Gstp1 ; Tnf ; Asthma ; Wheeze ; Gene-environment; S-transferase P1 ; Geographic Information-systems ; Land-use Regression ; 3 European Areas ; Allergic Sensitization ; Respiratory Health ; Children ; Contrasts ; Symptoms ; Exposure
Sprache englisch
Veröffentlichungsjahr 2013
HGF-Berichtsjahr 2013
ISSN (print) / ISBN 0393-2990
e-ISSN 1573-7284
Zeitschrift European Journal of Epidemiology
Quellenangaben Band: 28, Heft: 7, Seiten: 597-606 Artikelnummer: , Supplement: ,
Verlag Springer
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-503900-001
PubMed ID 23880893
DOI 10.1007/s10654-013-9828-5
WOS ID WOS:000323836900008
Scopus ID 84884246089
Erfassungsdatum 2013-09-27
[➜Korrektur melden]