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Mohajerani, P. ; Meier, R.* ; Noel, P.B.* ; Rummeny, E.J.* ; Ntziachristos, V.

Spatiotemporal analysis for indocyanine green-aided imaging of rheumatoid arthritis in hand joints.

J. Biomed. Opt. 18:97004 (2013)
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ABSTRACT. Rheumatoid arthritis (RA) is the most common chronic inflammatory joint disease, with a prevalence of 0.5 to 1% in the general population. Imaging can possibly aid in early diagnosis, crucial to effective personalized therapeutic strategies and treatment follow-up. The intravenous administration of indocyanine green (ICG) has been considered for identifying synovial hyperperfusion as an RA physiological biomarker. However, while the distribution of ICG in the human hand is a time-dependent process, the particular biodistribution dynamic patterns established following intravenous administration have not yet been studied. For this reason, the dynamic relationships of ICG distribution in the human hand in RA patients using a method based on principal component analysis are analyzed. In vivo analyses were corroborated by simulations of clinical scenarios using a finite element method. Observations of spatiotemporal characteristics are contrasted to fluorescence intensity images and magnetic resonance images of the hand joints, employed as the anatomical and diagnostic reference. Processing results for 450 joints from 5 healthy volunteers and 10 patients show that image features obtained from the spatiotemporal analysis offer good congruence with synovitis and reveal better detection performance compared to observations of raw fluorescence intensity images.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Rheumatoid arthritis; Indocyanine green; Planar fluorescence imaging; Epi-illumination imaging; Magnetic resonance imaging; Finite element modeling; Principal component analysis; Diffuse Optical Tomography ; Near-infrared Fluorescence ; Finger Joints ; Conventional Radiography ; Computed-tomography ; Angiography ; Contrast ; Distance ; Breast ; Osteoarthritis
Sprache englisch
Veröffentlichungsjahr 2013
HGF-Berichtsjahr 2013
ISSN (print) / ISBN 1083-3668
e-ISSN 1560-2281
Zeitschrift Journal of Biomedical Optics
Quellenangaben Band: 18, Heft: 9, Seiten: , Artikelnummer: 97004 Supplement: ,
Verlag SPIE
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-505500-001
PubMed ID 24045692
DOI 10.1117/1.JBO.18.9.097004
WOS ID WOS:000324747300021
Scopus ID 84887841665
Erfassungsdatum 2013-10-02
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