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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Association of variants in the BAT1-NFKBIL1-LTA genomic region with protection against myocardial infarction in Europeans.
Hum. Mol. Genet. 16, 1821-1827 (2007)
Verlagsversion Volltext
DOI
PMC
Single-nucleotide polymorphisms within the BAT1-NFKBIL1-LTA genomic region (6p21.3) and the LGALS2 gene (22q13.1), encoding a regulator for lymphotoxin-alpha, the product of the LTA gene, have been reported to be linked with the risk of myocardial infarction in Japanese. We employed nine polymorphisms from the BAT1-NFKBIL1-LTA region and one polymorphism from the LGALS2 gene, and investigated whether such associations were also present in Europeans. The study included 3657 patients with myocardial infarction and 1211 control individuals with angiographically normal coronary arteries. Minor homozygous genotypes of polymorphisms in BAT1 (rs2239527, -23C/G), NFKBIL1 (rs2071592, -63T/A) and LTA (rs1800683, -162G/A; rs909253, 252G/A; rs1041981, Thr26Asn) were associated with moderately protective effects against myocardial infarction (P
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
8.099
0.000
23
18
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
LYMPHOTOXIN-ALPHA GENE; SINGLE-NUCLEOTIDE POLYMORPHISMS; HISTOCOMPATIBILITY COMPLEX; SUSCEPTIBILITY LOCUS; HAPLOTYPE; DISEASE; ATHEROSCLEROSIS; PROMOTER; POPULATION; JAPANESE
Sprache
englisch
Veröffentlichungsjahr
2007
HGF-Berichtsjahr
2007
ISSN (print) / ISBN
0964-6906
e-ISSN
1460-2083
Zeitschrift
Human Molecular Genetics
Quellenangaben
Band: 16,
Heft: 15,
Seiten: 1821-1827
Verlag
Oxford University Press
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Human Genetics (IHG)
Institute of Epidemiology (EPI)
Institute of Epidemiology (EPI)
POF Topic(s)
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30503 - Chronic Diseases of the Lung and Allergies
30503 - Chronic Diseases of the Lung and Allergies
Forschungsfeld(er)
Genetics and Epidemiology
PSP-Element(e)
G-500700-001
G-503900-001
G-503900-001
PubMed ID
17517687
WOS ID
WOS:000249500600005
Scopus ID
34547839802
Erfassungsdatum
2007-11-22