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Gössner, W. ; Hug, O. ; Luz, A. ; Müller, W.A.

Experimental induction of bone tumors by short-lived bone-seeking radionuclides.

Recent Results Cancer Res., 36-49 (1976)
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Single and repeated applications of 224Ra and single applications of 227Th to more than 600 female NMRI mice 3 - 4 weeks old, and to male NMRI mice have led to a high rate of osteosarcomas. Tumor incidence is dose-related. 227Th is more carcinogenic than 224Ra which induced the highest tumor incidence of 60% after a single injection of 5 muCi per Kg body weight or more. Repeated injections of 224Ra to female mice yielded a tumor incidence of up to 92%. Most of these osteosarcomas consist of well-differentiated bone-forming osteoplastic tissue. Half of the tumors occurred in the spine, particularly in the lumbar region. In protraction experiments, multifocal osteosarcomas have been observed. Less than 10% of the mice with osteosarcoma had developed metastases in lung, spleen, liver, and kidney. The possible mechanisms of the protraction effect are discussed.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 1976
HGF-Berichtsjahr 0
ISSN (print) / ISBN 0080-0015
Zeitschrift Recent Results in Cancer Research
Quellenangaben Band: , Heft: 54, Seiten: 36-49 Artikelnummer: , Supplement: ,
Verlag Springer
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Pathology (PATH)
PubMed ID 1070723
Erfassungsdatum 1976-12-31
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