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Then, C. ; Wahl, S. ; Kirchhofer, A.* ; Grallert, H. ; Krug, S. ; Kastenmüller, G. ; Römisch-Margl, W. ; Claussnitzer, M. ; Illig, T.* ; Heier, M. ; Meisinger, C. ; Adamski, J. ; Thorand, B. ; Huth, C. ; Peters, A. ; Prehn, C. ; Heukamp, I.* ; Laumen, H. ; Lechner, A. ; Hauner, H. ; Seissler, J.

Plasma metabolomics reveal alterations of sphingo- and glycerophospholipid levels in non-diabetic carriers of the transcription factor 7-like 2 polymorphism rs7903146.

PLoS ONE 8:e78430 (2013)
Verlagsversion Volltext DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Aims/Hypothesis Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene have been shown to display a powerful association with type 2 diabetes. The aim of the present study was to evaluate metabolic alterations in carriers of a common TCF7L2 risk variant. Methods Seventeen non-diabetic subjects carrying the T risk allele at the rs7903146 TCF7L2 locus and 24 subjects carrying no risk allele were submitted to intravenous glucose tolerance test and euglycemic-hyperinsulinemic clamp. Plasma samples were analysed for concentrations of 163 metabolites through targeted mass spectrometry. Results TCF7L2 risk allele carriers had a reduced first-phase insulin response and normal insulin sensitivity. Under fasting conditions, carriers of TCF7L2 rs7903146 exhibited a non-significant increase of plasma sphingomyelins (SMs), phosphatidylcholines (PCs) and lysophosphatidylcholines (lysoPCs) species. A significant genotype effect was detected in response to challenge tests in 6 SMs (C16:0, C16:1, C18:0, C18:1, C24:0, C24:1), 5 hydroxy-SMs (C14:1, C16:1, C22:1, C22:2, C24:1), 4 lysoPCs (C14:0, C16:0, C16:1, C17:0), 3 diacyl-PCs (C28:1, C36:6, C40:4) and 4 long-chain acyl-alkyl-PCs (C40:2, C40:5, C44:5, C44:6).
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Type-2 Diabetes-mellitus ; Secretory Phospholipase A(2) ; Scale Association Analysis ; Insulin-resistance ; Tcf7l2 Gene ; Adipose-tissue ; Risk ; Metabolism ; Acid ; Increases
Sprache englisch
Veröffentlichungsjahr 2013
HGF-Berichtsjahr 2013
ISSN (print) / ISBN 1932-6203
Zeitschrift PLoS ONE
Quellenangaben Band: 8, Heft: 10, Seiten: , Artikelnummer: e78430 Supplement: ,
Verlag Public Library of Science (PLoS)
Verlagsort Lawrence, Kan.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Experimental Genetics (IEG)
Research Unit Molecular Epidemiology (AME)
Institute of Bioinformatics and Systems Biology (IBIS)
Institute of Epidemiology (EPI)
Molekulare Endokrinologie und Metabolismus (MEM)
CCG Nutrigenomics and Type 2 Diabetes (KKG-KDN)
POF Topic(s)
30201 - Metabolic Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30505 - New Technologies for Biomedical Discoveries
30202 - Environmental Health
90000 - German Center for Diabetes Research
30502 - Diabetes: Pathophysiology, Prevention and Therapy
Forschungsfeld(er)
Genetics and Epidemiology
Enabling and Novel Technologies
PSP-Element(e) G-521500-001
G-521500-002
G-504200-003
G-503700-001
G-504000-006
G-504000-002
G-505600-001
G-501900-401
G-521600-002
PubMed ID 24205203
DOI 10.1371/journal.pone.0078430
WOS ID WOS:000326152300060
Scopus ID 84886256198
Erfassungsdatum 2013-11-05
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