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Gewies, A. ; Castineiras-Vilarino, M.* ; Ferch, U.* ; Jährling, N.* ; Heinrich, K.* ; Hoeckendorf, U.* ; Przemeck, G.K.H. ; Munding, M. ; Groß, O.* ; Schroeder, T. ; Horsch, M. ; Karran, E.L.* ; Majid, A.* ; Antonowicz, S.* ; Beckers, J. ; Hrabě de Angelis, M. ; Dodt, H.U.* ; Peschel, C.* ; Förster, I.* ; Dyer, M.J.S.* ; Ruland, J,

Prdm6 is essential for cardiovascular development in vivo.

PLoS ONE 8:e81833 (2013)
Verlagsversion PDF DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Members of the PRDM protein family have been shown to play important roles during embryonic development. Previous in vitro and in situ analyses indicated a function of Prdm6 in cells of the vascular system. To reveal physiological functions of Prdm6, we generated conditional Prdm6-deficient mice. Complete deletion of Prdm6 results in embryonic lethality due to cardiovascular defects associated with aberrations in vascular patterning. However, smooth muscle cells could be regularly differentiated from Prdm6-deficient embryonic stem cells and vascular smooth muscle cells were present and proliferated normally in Prdm6-deficient embryos. Conditional deletion of Prdm6 in the smooth muscle cell lineage using a SM22-Cre driver line resulted in perinatal lethality due to hemorrhage in the lungs. We thus identified Prdm6 as a factor that is essential for the physiological control of cardiovascular development.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Transcriptional Repressor Blimp-1 ; T-cell Homeostasis ; Vascular Development ; Smooth-muscle ; Endothelial-cells ; Breast-cancer ; Mice Lacking ; Yolk-sac ; Angiogenesis ; Gene
Sprache englisch
Veröffentlichungsjahr 2013
HGF-Berichtsjahr 2013
ISSN (print) / ISBN 1932-6203
Zeitschrift PLoS ONE
Quellenangaben Band: 8, Heft: 11, Seiten: , Artikelnummer: e81833 Supplement: ,
Verlag Public Library of Science (PLoS)
Verlagsort Lawrence, Kan.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Molecular Toxicology and Pharmacology (TOX)
Institute of Experimental Genetics (IEG)
Research Unit Stem Cell Dynamics (SCD)
POF Topic(s)
30201 - Metabolic Health
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er)
Genetics and Epidemiology
Stem Cell and Neuroscience
PSP-Element(e) G-505291-001
G-500600-003
G-500600-004
G-501200-001
PubMed ID 24278461
DOI 10.1371/journal.pone.0081833
WOS ID WOS:000327539800143
Scopus ID 84896695806
Scopus ID 84894265231
Erfassungsdatum 2013-11-22
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