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Sim, N.* ; Gottschalk, S. ; Pal, R.* ; Engelmann, J.* ; Parker, D.* ; Mishra, A.

Responsive MR-imaging probes for N-methyl-_^D-aspartate receptors and direct visualisation of the cell-surface receptors by optical microscopy.

Chem. Sci. 4, 3148-3153 (2013)

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A series of N-methyl-D-aspartate (NMDA) receptor-targeted MRI contrast agents has been developed, based on the known competitive NMDA antagonist, 3,4-diamino-3-cyclobutene-1,2-dione. Their use as responsive MR imaging probes has been evaluated in vitro and two contrast agents showed 170–176% enhancements in relaxation rate, following incubation with a neuronal cell line model. A derivative of the lead compound was prepared containing a biotin moiety, and both the specificity and reversibility of binding to the NMDA cell surface receptors demonstrated using confocal microscopy.

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