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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Brain metastasis in renal cancer patients: Metastatic pattern, tumour-associated macrophages and chemokine/chemoreceptor expression.
Br. J. Cancer 110, 686-694 (2014)
Verlagsversion
DOI
PMC
Background:The mechanisms of brain metastasis in renal cell cancer (RCC) patients are poorly understood. Chemokine and chemokine receptor expression may contribute to the predilection of RCC for brain metastasis by recruitment of monocytes/macrophages and by control or induction of vascular permeability of the blood-brain barrier.Methods:Frequency and patterns of brain metastasis were determined in 246 patients with metastatic RCC at autopsy. Expression of CXCR4, CCL7 (MCP-3), CCR2 and CD68+ tumour-associated macrophages (TAMs) were analysed in a separate series of 333 primary RCC and in 48 brain metastases using immunohistochemistry.Results:Fifteen percent of 246 patients with metastasising RCC had brain metastasis. High CXCR4 expression levels were found in primary RCC and brain metastases (85.7% and 91.7%, respectively). CCR2 (52.1%) and CCL7 expression (75%) in cancer cells of brain metastases was more frequent compared with primary tumours (15.5% and 16.7%, respectively; P<0.0001 each). The density of CD68+ TAMs was similar in primary RCC and brain metastases. However, TAMs were more frequently CCR2-positive in brain metastases than in primary RCC (P<0.001).Conclusion:Our data demonstrate that the monocyte-specific chemokine CCL7 and its receptor CCR2 are expressed in tumour cells of RCC. We conclude that monocyte recruitment by CCR2 contributes to brain metastasis of RCC.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
5.082
1.633
49
53
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Renal Cancer ; Metastasis ; Cxcr4 ; Ccl7 (mcp-3) ; Ccr2 ; Tumour-associated Macrophages; Central-nervous-system; Monocyte Chemoattractant Protein-1; Chemokine Receptor Expression; Cell Carcinoma; Breast-cancer; Biological Axis; Cxcr4; Survival; Ccl2; Barrier
Sprache
Veröffentlichungsjahr
2014
Prepublished im Jahr
2013
HGF-Berichtsjahr
2013
ISSN (print) / ISBN
0007-0920
e-ISSN
1532-1827
Zeitschrift
British Journal of Cancer BJC
Quellenangaben
Band: 110,
Heft: 3,
Seiten: 686-694
Verlag
Nature Publishing Group
Verlagsort
London
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Virology (VIRO)
POF Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er)
Immune Response and Infection
PSP-Element(e)
G-551600-001
WOS ID
WOS:000331226400018
PubMed ID
24327013
Erfassungsdatum
2013-12-31