PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Siroux, V.* ; Gonzalez, J.R.* ; Bouzigon, E.* ; Curjuric, I.* ; Boudier, A.* ; Imboden, M.* ; Antò, J.M.* ; Gut, I.* ; Jarvis, D.* ; Lathrop, M* ; Omenaas, E.R.* ; Pin, I.* ; Wjst, M. ; Demenais, F.* ; Probst-Hensch, N.* ; Kogevinas, M.* ; Kauffmann, F.*

Genetic heterogeneity of asthma phenotypes identified by a clustering approach.

Eur. Respir. J. 43, 439-452 (2014)
Verlagsversion DOI PMC
Closed
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The aim was to identify genetic variants associated with refined asthma phenotypes enabling to take into account multiple features of the disease.Latent class analysis (LCA) was applied in 3001 adults ever having asthma recruited in the frame of three epidemiological surveys (ECRHS, SAPALDIA, EGEA). Fourteen personal and phenotypic characteristics from questionnaires and clinical examination were used. A genome wide association study (GWAS) was conducted for each LCA-derived asthma phenotype, compared to subjects without asthma (n=3474).The LCA identified four adult asthma phenotypes, mainly characterized by the activity of the disease, the age of asthma onset and the atopic status. Associations of genome wide significance (<1.25×10-7) were observed between "active adult-onset non-allergic asthma" and rs9851461 flanking CD200 (3q13.2) and between "Inactive/mild non-allergic asthma" and rs2579931 flanking GRIK2 (6q16.3). Borderline significant results (2.5×10(-7).
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
6.355
2.411
20
44
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Genome-wide Association; Childhood Asthma; Lung-function; Variants; Diseases; Risk; Loci; Susceptibility; Environment; Population
Sprache englisch
Veröffentlichungsjahr 2014
Prepublished im Jahr 2013
HGF-Berichtsjahr 2013
ISSN (print) / ISBN 0903-1936
e-ISSN 1399-3003
Zeitschrift European Respiratory Journal
Quellenangaben Band: 43, Heft: 2, Seiten: 439-452 Artikelnummer: , Supplement: ,
Verlag European Respiratory Society
Verlagsort Sheffield
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Lung Research
PSP-Element(e) G-505000-003
PubMed ID 24311777
DOI 10.1183/09031936.00032713
WOS ID WOS:000330824500017
Scopus ID 84893454185
Erfassungsdatum 2013-12-31
[➜Korrektur melden]