PuSH - Publikationsserver des Helmholtz Zentrums München: A prime-boost vaccination protocol optimizes immune responses against the nucleocapsid protein of the SARS coronavirus.

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Schulze, K.* ; Staib, C. ; Schatzl, H.M.* ; Ebensen, T.* ; Erfle, V. ; Guzman, C.A.*

A prime-boost vaccination protocol optimizes immune responses against the nucleocapsid protein of the SARS coronavirus.

Vaccine 26, 6678-6684 (2008)

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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

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Severe acute respiratory syndrome (SARS) is a Serious infectious disease Caused by the SARS coronavirus. We assessed the potential of prime-boost vaccination protocols based oil the nucleocapsid (NC) protein co-administered with a derivative of the mucosal adjuvant MALP-2 or expressed by modified Vaccinia virus Ankara (MVA-NC) to stimulate humoral and cellular immune responses at systemic and mucosal levels. The obtained results demonstrated that strong immune responses can be elicited both at systemic and mucosal levels following a heterologous prime-boost vaccination protocol consisting in pruning with NC protein add-mixed with MALP-2 by intranasal route and boosting with MVA-NC by intramuscular route.

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