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Migliorini, A. ; Bader, E. ; Lickert, H.

Islet cell plasticity and regeneration.

Mol. Metab. 3, 268–274 (2014)
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Creative Commons Lizenzvertrag
Insulin-dependent diabetes is a complex multifactorial disorder characterized by loss or dysfunction of β-cells resulting in failure of metabolic control. Even though type 1 and 2 diabetes differ in their pathogenesis, restoring β-cell function is the overarching goal for improved therapy of both diseases. This could be achieved either by cell-replacement therapy or by triggering intrinsic regenerative mechanisms of the pancreas. For type 1 diabetes, a combination of β-cell replacement and immunosuppressive therapy could be a curative treatment, whereas for type 2 diabetes enhancing endogenous mechanisms of β-cell regeneration might optimize blood glucose control. This review will briefly summarize recent efforts to allow β-cell regeneration where the most promising approaches are currently (1) increasing β-cell self-replication or neogenesis from ductal progenitors and (2) conversion of α-cells into β-cells.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter β-cell Neogenesis ; β-cell Proliferation ; β-cell Regeneration ; Diabetes ; Islet Architecture ; Pancreas Plasticity
Sprache
Veröffentlichungsjahr 2014
HGF-Berichtsjahr 2014
ISSN (print) / ISBN 2212-8778
e-ISSN 2212-8778
Zeitschrift Molecular Metabolism
Quellenangaben Band: 3, Heft: 3, Seiten: 268–274 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Regeneration Research (IDR)
Institute of Epidemiology (EPI)
Institute of Stem Cell Research (ISF)
POF Topic(s) 30201 - Metabolic Health
30202 - Environmental Health
30204 - Cell Programming and Repair
90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
Genetics and Epidemiology
Stem Cell and Neuroscience
PSP-Element(e) G-502300-001
G-504091-003
G-500800-001
G-501900-231
PubMed ID 24749056
DOI 10.1016/j.molmet.2014.01.010
Scopus ID 84893753183
Scopus ID 84897114022
Erfassungsdatum 2014-02-23
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