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Warncke, K.* ; Dressel, P.* ; Ziegler, A.-G. ; Steinborn, M.* ; Bonfig, W.* ; Burdach, S.* ; Engelsberger, I.*

Severe pretreatment cerebral edema in newly diagnosed type 1 diabetes.

Horm. Res. Paediatr. 81, 285-288 (2014)
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Introduction: Cerebral edema (CE) is a rare and dangerous complication of diabetic ketoacidosis. In typical cases, it may develop during several hours after the beginning of ketoacidosis therapy. Nevertheless, CE sometimes occurs before the start of any therapy - as for the patient in this report here. Case Report: We describe a 12-year-old girl with newly diagnosed type 1 diabetes, presenting with severe headache and disorientation. Diabetes-related symptoms were not reported by the family. Clinical investigation revealed signs of meningeal irritation and Kussmaul breathing. In the laboratory, severe ketoacidosis (pH 6.95) and hyperglycemia (blood glucose 20.9 mmmol/l) were found. Cranial computed tomography showed CE. The patient was treated with a very cautious fluid and insulin therapy and recovered within 3 days. MRI after recovery showed normal findings without residuals of CE. Conclusion: CE before any treatment of ketoacidosis is a very rare complication of type 1 diabetes. Early diagnosis and effective treatment are extremely important for the patient's outcome and prognosis.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Type 1 Diabetes ; Rapid Progression ; Neurological Symptoms ; Ketoacidosis ; Cerebral Edema; Risk-factors; Ketoacidosis; Children
Sprache englisch
Veröffentlichungsjahr 2014
HGF-Berichtsjahr 2014
ISSN (print) / ISBN 1663-2818
e-ISSN 1663-2826
Quellenangaben Band: 81, Heft: 4, Seiten: 285-288 Artikelnummer: , Supplement: ,
Verlag Karger
Verlagsort Basel
Begutachtungsstatus Peer reviewed
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502100-001
PubMed ID 24642459
Scopus ID 84901621516
Erfassungsdatum 2014-03-28