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Mook-Kanamori, D.O.* ; Römisch-Margl, W. ; Kastenmüller, G. ; Prehn, C. ; Petersen, A.K. ; Illig, T.* ; Gieger, C. ; Wang-Sattler, R. ; Meisinger, C. ; Peters, A. ; Adamski, J. ; Suhre, K.

Increased amino acids levels and the risk of developing hypertriglyceridemia in a 7-year follow-up.

J. Endocrinol. Invest. 37, 369-374 (2014)
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Background Recently, five branched-chain and aromatic amino acids were shown to be associated with the risk of developing type 2 diabetes (T2D). Aim We set out to examine whether amino acids are also associated with the development of hypertriglyceridemia. Materials and methods We determined the serum amino acids concentrations of 1,125 individuals of the KORA S4 baseline study, for which follow-up data were available also at the KORA F4 7 years later. After exclusion for hypertriglyceridemia (defined as having a fasting triglyceride level above 1.70 mmol/L) and diabetes at baseline, 755 subjects remained for analyses. Results Increased levels of leucine, arginine, valine, proline, phenylalanine, isoleucine and lysine were significantly associated with an increased risk of hypertriglyceridemia. These associations remained significant when restricting to those individuals who did not develop T2D in the 7-year follow-up. The increase per standard deviation of amino acid level was between 26 and 40 %. Conclusions Seven amino acids were associated with an increased risk of developing hypertriglyceridemia after 7 years. Further studies are necessary to elucidate the complex role of these amino acids in the pathogenesis of metabolic disorders.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Amino acids; Hypertriglyceridemia; Insulin-resistance; Cardiovascular-disease; Heart-disease; Acylcarnitines; Population; Metabolism; Obesity; Humans; Kora
Sprache englisch
Veröffentlichungsjahr 2014
HGF-Berichtsjahr 2014
ISSN (print) / ISBN 0391-4097
e-ISSN 1720-8386
Zeitschrift Journal of Endocrinological Investigation
Quellenangaben Band: 37, Heft: 4, Seiten: 369-374 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort New York
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Bioinformatics and Systems Biology (IBIS)
Molekulare Endokrinologie und Metabolismus (MEM)
Institute of Experimental Genetics (IEG)
Institute of Genetic Epidemiology (IGE)
Institute of Epidemiology (EPI)
POF Topic(s) 30505 - New Technologies for Biomedical Discoveries
30201 - Metabolic Health
90000 - German Center for Diabetes Research
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30202 - Environmental Health
Forschungsfeld(er) Enabling and Novel Technologies
Genetics and Epidemiology
PSP-Element(e) G-503700-001
G-505600-001
G-505600-003
G-501900-061
G-504100-001
G-504091-003
G-504000-006
G-504090-001
PubMed ID 24682914
DOI 10.1007/s40618-013-0044-7
WOS ID WOS:000335152400008
Scopus ID 84900527122
Erfassungsdatum 2014-04-01
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