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Fowkes, F.G.R.* ; Murray, G.D.* ; Butcher, I.* ; Folsom, A.R.* ; Hirsch, A.T.* ; Couper, D.J.* ; Debacker, G.* ; Kornitzer, M.* ; Newman, A.B.* ; Sutton-Tyrrell, K.C.* ; Cushman, M.* ; Lee, A.J.* ; Price, J.F.* ; D'Agostino, R.B.* ; Murabito, J.M.* ; Norman, P.E.* ; Masaki, K.H.* ; Bouter, L.M.* ; Heine, R.J.* ; Stehouwer, C.D.A.* ; McDermott, M.M.* ; Stoffers, H.E.J.H.* ; Knottnerus, J.A.* ; Ogren, M.* ; Hedblad, B.* ; Koenig, W.* ; Meisinger, C. ; Cauley, J.A.* ; Franco, O.H.* ; Hunink, M.G.M.* ; Hofman, A.* ; Witteman, J.C.* ; Criqui, M.H.* ; Langer, R.D.* ; Hiatt, W.R.* ; Hamman, R.F.*

Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events.

Eur. J. Prev. Cardiol. 21, 310-320 (2014)

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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

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Background: The ankle brachial index (ABI) is related to risk of cardiovascular events independent of the Framingham risk score (FRS). The aim of this study was to develop and evaluate a risk model for cardiovascular events incorporating the ABI and FRS. Design: An analysis of participant data from 18 cohorts in which 24,375 men and 20,377 women free of coronary heart disease had ABI measured and were followed up for events. Methods: Subjects were divided into a development and internal validation dataset and an external validation dataset. Two models, comprising FRS and FRS+ABI, were fitted for the primary outcome of major coronary events.

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