PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Meinel, F.G. ; Yaroshenko, A.* ; Hellbach, K.* ; Bech, M.* ; Müller, M.* ; Velroyen, A.* ; Bamberg, F.* ; Eickelberg, O. ; Nikolaou, K.* ; Reiser, M.F.* ; Pfeiffer, F.* ; Yildirim, A.Ö.

Improved diagnosis of pulmonary emphysema using in vivo dark-field radiography.

Invest. Radiol. 49, 653-658 (2014)
Verlagsversion DOI PMC
Open Access Gold
OBJECTIVES: The purpose of this study was to assess whether the recently developed method of grating-based x-ray dark-field radiography can improve the diagnosis of pulmonary emphysema in vivo. MATERIALS AND METHODS: Pulmonary emphysema was induced in female C57BL/6N mice using endotracheal instillation of porcine pancreatic elastase and confirmed by in vivo pulmonary function tests, histopathology, and quantitative morphometry. The mice were anesthetized but breathing freely during imaging. Experiments were performed using a prototype small-animal x-ray dark-field scanner that was operated at 35 kilovolt (peak) with an exposure time of 5 seconds for each of the 10 grating steps. Images were compared visually. For quantitative comparison of signal characteristics, regions of interest were placed in the upper, middle, and lower zones of each lung. Receiver-operating-characteristic statistics were performed to compare the effectiveness of transmission and dark-field signal intensities and the combined parameter "normalized scatter" to differentiate between healthy and emphysematous lungs. RESULTS: A clear visual difference between healthy and emphysematous mice was found for the dark-field images. Quantitative measurements of x-ray dark-field signal and normalized scatter were significantly different between the mice with pulmonary emphysema and the control mice and showed good agreement with pulmonary function tests and quantitative histology. The normalized scatter showed a significantly higher discriminatory power (area under the receiver-operating-characteristic curve [AUC], 0.99) than dark-field (AUC, 0.90; P = 0.01) or transmission signal (AUC, 0.69; P < 0.001) alone did, allowing for an excellent discrimination of healthy and emphysematous lung regions. CONCLUSIONS: In a murine model, x-ray dark-field radiography is technically feasible in vivo and represents a substantial improvement over conventional transmission-based x-ray imaging for the diagnosis of pulmonary emphysema.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
4.453
1.782
37
45
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter X-ray Dark-field Imaging ; X-ray Phase-contrast Imaging ; Pulmonary Emphysema; Contrast Computed-tomography; Ray; Chest; Disease; Lungs; Ct
Sprache englisch
Veröffentlichungsjahr 2014
HGF-Berichtsjahr 2014
ISSN (print) / ISBN 0020-9996
e-ISSN 1536-0210
Zeitschrift Investigative Radiology
Quellenangaben Band: 49, Heft: 10, Seiten: 653-658 Artikelnummer: , Supplement: ,
Verlag Lippincott Williams & Wilkins
Verlagsort Hagerstown, Md.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)
POF Topic(s) 30202 - Environmental Health
80000 - German Center for Lung Research
Forschungsfeld(er) Lung Research
PSP-Element(e) G-505000-007
G-501600-001
G-505000-006
G-501800-805
PubMed ID 24853070
DOI 10.1097/RLI.0000000000000067
WOS ID WOS:000342379000004
Erfassungsdatum 2014-05-25
[➜Korrektur melden]