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Thaler, J.P.* ; Yi, C.-X. ; Schur, E.A.* ; Guyenet, S.J.* ; Hwang, B.H.* ; Dietrich, M.O.* ; Zhao, X.* ; Sarruf, D.A.* ; Izgur, V.* ; Maravilla, K.R.* ; Nguyen, H.T.* ; Fischer, J.D.* ; Matsen, M.E.* ; Wisse, B.E.* ; Morton, G.J.* ; Horvath, T.L.* ; Baskin, D.G.* ; Tschöp, M.H.* ; Schwartz, M.W.*

Obesity is associated with hypothalamic injury in rodents and humans.

J. Clin. Invest. 122, 153-162 (2012)
DOI PMC
Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.
Rodent models of obesity induced by consuming high-fat diet (HFD) are characterized by inflammation both in peripheral tissues and in hypothalamic areas critical for energy homeostasis. Here we report that unlike inflammation in peripheral tissues, which develops as a consequence of obesity, hypothalamic inflammatory signaling was evident in both rats and mice within 1 to 3 days of HFD onset, prior to substantial weight gain. Furthermore, both reactive gliosis and markers suggestive of neuron injury were evident in the hypothalamic arcuate nucleus of rats and mice within the first week of HFD feeding. Although these responses temporarily subsided, suggesting that neuroprotective mechanisms may initially limit the damage, with continued HFD feeding, inflammation and gliosis returned permanently to the mediobasal hypothalamus. Consistent with these data in rodents, we found evidence of increased gliosis in the mediobasal hypothalamus of obese humans, as assessed by MRI. These findings collectively suggest that, in both humans and rodent models, obesity is associated with neuronal injury in a brain area crucial for body weight control.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2012
HGF-Berichtsjahr 0
ISSN (print) / ISBN 0021-9738
e-ISSN 1558-8238
Zeitschrift Journal of Clinical Investigation
Quellenangaben Band: 122, Heft: 1, Seiten: 153-162 Artikelnummer: , Supplement: ,
Verlag American Society of Clinical Investigation
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502200-001
PubMed ID 22201683
DOI 10.1172/JCI59660
Erfassungsdatum 2012-12-31
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