PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Schmid, M.-T. ; Weinandy, F. ; Wilsch-Bräuninger, M.* ; Huttner, W.B.* ; Cappello, S. ; Götz, M.

The role of α-E-catenin in cerebral cortex development: Radial glia specific effect on neuronal migration.

Front. Cell. Neurosci. 8:215 (2014)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
During brain development, radial glial cells possess an apico-basal polarity and are coupled by adherens junctions (AJs) to an F-actin belt. To elucidate the role of the actin, we conditionally deleted the key component α-E-catenin in the developing cerebral cortex. Deletion at early stages resulted in severe disruption of tissue polarity due to uncoupling of AJs with the intracellular actin fibers leading to the formation of subcortical band heterotopia. Interestingly, this phenotype closely resembled the phenotype obtained by conditional RhoA deletion, both in regard to the macroscopic subcortical band heterotopia and the subcellular increase in G-actin/F-actin ratio. These data therefore together corroborate the role of the actin cytoskeleton and its anchoring to the AJs for neuronal migration disorders.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
4.175
0.776
27
24
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Actin ; Adherens Junctions ; Cell Polarity ; Neuronal Migration ; Subcortical Band Heterotopia ; α-e-catenin; Progenitor Cells; Beta-catenin; N-catenin; Cortical Development; Subventricular Zone; Neural Progenitors; Adherens Junctions; Pyramidal Neurons; Epithelial-cells; Apical Surface
Sprache englisch
Veröffentlichungsjahr 2014
HGF-Berichtsjahr 2014
e-ISSN 1662-5102
Zeitschrift Frontiers in Cellular Neuroscience
Quellenangaben Band: 8, Heft: , Seiten: , Artikelnummer: 215 Supplement: ,
Verlag Frontiers
Verlagsort Lausanne
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Stem Cell Research (ISF)
POF Topic(s) 30204 - Cell Programming and Repair
Forschungsfeld(er) Stem Cell and Neuroscience
PSP-Element(e) G-500800-001
PubMed ID 25147501
DOI 10.3389/fncel.2014.00215
WOS ID WOS:000339936300002
Scopus ID 84905689879
Erfassungsdatum 2014-08-27
[➜Korrektur melden]