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Yi, C.-X. ; Habegger, K.M.* ; Chowen, J.A.* ; Stern, J.* ; Tschöp, M.H.

A role for astrocytes in the central control of metabolism.

Neuroendocrinology 93, 143-149 (2011)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Over the last decades, the negative health consequences of obesity have triggered massive searches for the cause of --and potential solutions for--the excessive mismatch between calorie consumption and expenditure. The concepts of malfunctioning hypothalamic neurotransmission and impaired related neuromodulatory networks in other brain regions have attracted considerable attention as they may partially explain metabolic abnormalities. While numerous and important efforts are underway to scientifically dissect the neuronal signaling pathways involved in metabolic sensing and regulation, the roles of astroglial cells represent a relatively understudied area. This gap in knowledge is particularly evident in the neuroendocrine control of glucose and lipid metabolism. This review presents evidence that in regard to metabolism, astrocytes act not only as an energy supplier for neurons, but may also play key roles in metabolic sensing by expressing metabolic related receptors and regulators. Moreover, the astrocytosis observed during calorie-rich high-fat diet indicates that astrocytes could be involved in developing metabolic abnormalities. Finally, potential obstacles and pitfalls for studying the role of astrocytes in metabolic sensing and regulation are discussed.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2011
HGF-Berichtsjahr 0
ISSN (print) / ISBN 0028-3835
e-ISSN 1423-0194
Zeitschrift Neuroendocrinology
Quellenangaben Band: 93, Heft: 3, Seiten: 143-149 Artikelnummer: , Supplement: ,
Verlag Karger
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502200-001
PubMed ID 21372559
DOI 10.1159/000324888
Erfassungsdatum 2011-12-31
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