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Heppner, K.M.* ; Lehti, M.* ; Day, J.* ; Pfluger, P.T.* ; Perez-Tilve, D.* ; Ward, B.* ; Gelfanov, V.* ; Woods, S.C.* ; DiMarchi, R.* ; Tschöp, M.H.*

Glucagon regulation of energy metabolism.

Physiol. Behav. 100, 545-548 (2010)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Glucagon has long been known as a counter-regulatory hormone to insulin of fundamental importance to glucose homeostasis. Its prominent ability to stimulate glycogenolysis and gluconeogenesis, has historically cast this peptide as one hormone where the metabolic consequences of increasing blood glucose levels, especially in obesity, are viewed largely as being deleterious. This perspective may be changing in light of emerging data and reconsideration of historic studies, which suggest that glucagon has beneficial effects on body fat mass, food intake, and energy expenditure. In this review, we discuss the mechanisms of glucagon-mediated body weight regulation as well as possible novel therapeutic approaches in the treatment of obesity and glucose intolerance that may arise from these findings. The paper represents an invited review by a symposium, award winner or keynote speaker at the Society for the Study of Ingestive Behavior [SSIB] Annual Meeting in Portland, July 2009.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2010
HGF-Berichtsjahr 0
ISSN (print) / ISBN 0031-9384
e-ISSN 1873-507X
Zeitschrift Physiology & Behavior
Quellenangaben Band: 100, Heft: 5, Seiten: 545-548 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
PubMed ID 20381509
DOI 10.1016/j.physbeh.2010.03.019
WOS ID 000279988100017
Erfassungsdatum 2010-12-31
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