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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Predicting type 1 diabetes.
Curr. Diab. Rep. 5, 98-103 (2005)
Predicting type 1 diabetes mellitus (T1DM) is a prerequisite for disease prevention. Prediction is currently performed on three levels, which include the genetic susceptibility for disease, the identification of preclinical T1DM by way of circulating islet autoantibodies, and the use of metabolic tests to stage preclinical disease into late or early prediabetes. Combinations of genetic markers such as HLA genotype, INS genotype, and if and how much family history of T1DM is present can stratify disease risk more than 1000-fold, and can be used for selection of first-degree relatives of patients with T1DM for primary intervention trials. Measurement of autoantibodies in genetically at-risk subjects identifies future cases of T1DM. Further stratification of diabetes risk in autoantibody-positive subjects can be made on the basis of autoantibody characteristics that correspond to the magnitude of the autoantibody response.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Sprache
englisch
Veröffentlichungsjahr
2005
HGF-Berichtsjahr
0
ISSN (print) / ISBN
1534-4827
e-ISSN
1539-0829
Zeitschrift
Current Diabetes Reports
Quellenangaben
Band: 5,
Heft: 2,
Seiten: 98-103
Verlag
Springer
Verlagsort
Heidelberg [u.a.]
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Diabetes Research (IDF)
Institute of Diabetes and Obesity (IDO)
Institute of Pancreatic Islet Research (IPI)
Institute of Diabetes and Obesity (IDO)
Institute of Pancreatic Islet Research (IPI)
POF Topic(s)
30201 - Metabolic Health
30502 - Diabetes: Pathophysiology, Prevention and Therapy
30502 - Diabetes: Pathophysiology, Prevention and Therapy
Forschungsfeld(er)
Helmholtz Diabetes Center
PSP-Element(e)
G-502100-001
G-502290-001
G-502290-001
PubMed ID
15794911
Erfassungsdatum
2005-04-00