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Keymeulen, B.* ; Candon, S.* ; Fafi-Kremer, S.* ; Ziegler, A.* ; Leruez-Ville, M.* ; Mathieu, C.* ; Vandemeulebroucke, E.* ; Walter, M.* ; Crenier, L.* ; Thervet, E.* ; Legendre, C.* ; Pierard, D.* ; Hale, G.* ; Waldmann, H.* ; Bach, J.F.* ; Seigneurin, J.M.* ; Pipeleers, D.* ; Chatenoud, L.*

Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients.

Blood 115, 1145-55 (2010)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Here we report a unique situation in which an early and synchronized Epstein-Barr virus (EBV) reactivation was induced by a 6-day course of treatment with a humanized CD3-specific monoclonal antibody in patients with recent onset of type 1 diabetes. The virologic and immunologic analysis demonstrated that this reactivation was transient, self-limited, and isolated, associated with the rapid advent of an EBV-specific T-cell response. The anti-CD3 antibody administration induced short-lasting immunosuppression and minor yet clear-cut signs of T-cell activation that preceded viral reactivation. Early posttransplant monitoring of renal and islet allograft recipients showed that no comparable phenomenon was observed after the administration of full-dose immunosuppressive therapy. This EBV reactivation remains of no apparent clinical concern over the long term and should not preclude further development of therapeutic anti-CD3 antibodies. This phenomenon may also direct new research avenues to understand the still ill-defined nature of stimuli triggering EBV reactivation in vivo.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2010
HGF-Berichtsjahr 0
ISSN (print) / ISBN 0006-4971
e-ISSN 1528-0020
Zeitschrift Blood
Quellenangaben Band: 115, Heft: 6, Seiten: 1145-55 Artikelnummer: , Supplement: ,
Verlag American Society of Hematology
Verlagsort Washington, DC
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research (IDF)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502100-001
PubMed ID 20007541
DOI 10.1182/blood-2009-02-204875
WOS ID 000274431400009
Erfassungsdatum 2009-12-09
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