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Niedner, A. ; Edelmann, F* ; Niessing, D.

Of social molecules: The interactive assembly of ASH1 mRNA-transport complexes in yeast.

RNA Biol. 11, 998-1009 (2014)
Postprint DOI PMC
Open Access Green
Asymmetric, motor-protein dependent transport of mRNAs and subsequent localized translation is an important mechanism of gene regulation. Due to the high complexity of such motile particles, our mechanistic understanding of mRNA localization is limited. Over the last two decades, ASH1 mRNA localization in budding yeast has served as comparably simple and accessible model system. Recent advances have helped to draw an increasingly clear picture on the molecular mechanisms governing ASH1 mRNA localization from its co-transcriptional birth to its delivery at the site of destination. These new insights help to better understand the requirement of initial nuclear mRNPs, the molecular basis of specific mRNA-cargo recognition via cis-acting RNA elements, the different stages of RNP biogenesis and reorganization, as well as activation of the motile activity upon cargo binding. We discuss these aspects in context of published findings from other model organisms.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Ash1mrna ; Loc1p ; Myo4p ; Rna-binding Protein ; She2p ; She3p ; Endoplasmic Reticulum ; Mrna Localization ; Mrnp ; Myosin; Dsrna-binding Domain; Class-v Myosin; Pumilio-homology Domain; Fragile-x-syndrome; Neuronal Bc1 Rna; Saccharomyces-cerevisiae; Endoplasmic-reticulum; Crystal-structure; Budding Yeast; Translational Control
Sprache englisch
Veröffentlichungsjahr 2014
HGF-Berichtsjahr 2014
ISSN (print) / ISBN 1547-6286
e-ISSN 1555-8584
Zeitschrift RNA Biology
Quellenangaben Band: 11, Heft: 8, Seiten: 998-1009 Artikelnummer: , Supplement: ,
Verlag Landes Bioscience
Verlagsort Austin
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Structural Biology (STB)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-503091-001
PubMed ID 25180512
PubMed ID 25482892
DOI 10.4161/rna.29946
WOS ID WOS:000348382800004
Scopus ID 84920921335
Erfassungsdatum 2014-10-10
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