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Mölter, A.* ; Simpson, A.* ; Berdel, D.* ; Brunekreef, B.* ; Custovic, A.* ; Cyrys, J. ; de Jongste, J.* ; de Vocht, F.* ; Fuertes, E. ; Gehring, U.* ; Gruzieva, O.* ; Heinrich, J. ; Hoek, G.* ; Hoffmann, B.* ; Klümper, C.* ; Korek, M.* ; Kuhlbusch, T.A.J.* ; Lindley, S.* ; Postma, D.* ; Tischer, C.G. ; Wijga, A.* ; Pershagen, G.* ; Agius, R.M.*

A multicentre study of air pollution exposure and childhood asthma prevalence: The ESCAPE project.

Eur. Respir. J. 45, 610-624 (2015)
Verlagsversion DOI PMC
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The aim of this study was to determine the effect of six traffic-related air pollution metrics (nitrogen dioxide, nitrogen oxides, particulate matter with an aerodynamic diameter <10 μm (PM10), PM2.5, coarse particulate matter and PM2.5 absorbance) on childhood asthma and wheeze prevalence in five European birth cohorts: MAAS (England, UK), BAMSE (Sweden), PIAMA (the Netherlands), GINI and LISA (both Germany, divided into north and south areas). Land-use regression models were developed for each study area and used to estimate outdoor air pollution exposure at the home address of each child. Information on asthma and current wheeze prevalence at the ages of 4-5 and 8-10 years was collected using validated questionnaires. Multiple logistic regression was used to analyse the association between pollutant exposure and asthma within each cohort. Random-effects meta-analyses were used to combine effect estimates from individual cohorts. The meta-analyses showed no significant association between asthma prevalence and air pollution exposure (e.g. adjusted OR (95%CI) for asthma at age 8-10 years and exposure at the birth address (n = 10377): 1.10 (0.81-1.49) per 10 μg·m(-3) nitrogen dioxide; 0.88 (0.63-1.24) per 10 μg·m(-3) PM10; 1.23 (0.78-1.95) per 5 μg·m(-3) PM2.5). This result was consistently found in initial crude models, adjusted models and further sensitivity analyses. This study found no significant association between air pollution exposure and childhood asthma prevalence in five European birth cohorts.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Use Regression-models; Childrens Respiratory Symptoms; Long-term Exposure; Birth Cohort; Nitrogen-dioxide; Particulate Matter; Pm2.5 Absorbency; Lung-function; No2; Areas
Sprache englisch
Veröffentlichungsjahr 2015
Prepublished im Jahr 2014
HGF-Berichtsjahr 2014
ISSN (print) / ISBN 0903-1936
e-ISSN 1399-3003
Zeitschrift European Respiratory Journal
Quellenangaben Band: 45, Heft: 3, Seiten: 610-624 Artikelnummer: , Supplement: ,
Verlag European Respiratory Society
Verlagsort Sheffield
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-503900-001
G-504000-004
PubMed ID 25323237
DOI 10.1183/09031936.00083614
WOS ID WOS:000350701200010
Scopus ID 84923855568
Erfassungsdatum 2014-10-20
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