PuSH - Publikationsserver des Helmholtz Zentrums München: Common variants in the JAZF1 gene associated with height identified by linkage and genome-wide association analysis.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

EVA: Veröffentlichen

Neuer EVA Antrag

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Johansson, A.* ; Marroni, F.* ; Hayward, C.* ; Franklin, C.S.* ; Kirichenko, A.V.* ; Jonasson, I.* ; Hicks, A.A.* ; Vitart, V.* ; Isaacs, A.* ; Axenovich, T.* ; Campbell, S.* ; Dunlop, M.G* ; Floyd, J.* ; Hastie, N.* ; Hofman, A.* ; Knott, S.* ; Kolcic, I.* ; Pichler, I.* ; Polasek, O.* ; Rivadeneira, F.* ; Tenesa, A.* ; Uitterlinden, A.G.* ; Wild, S.H.* ; Zorkoltseva, I.V.* ; Meitinger, T. ; Wilson, J.F.* ; Rudan, I.* ; Campbell, H.* ; Pattaro, C.* ; Pramstaller, P.* ; Oostra, B.A.* ; Wright, A.F.* ; van Duijn, C.M.* ; Aulchenko, Y.S.* ; Gyllensten, U.*

Common variants in the JAZF1 gene associated with height identified by linkage and genome-wide association analysis.

Hum. Mol. Genet. 18, 373-380 (2009)

Verlagsversion Volltext

DOI

PMC

	Closed

Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

Abstract
Metriken
Zusatzinfos

Genes for height have gained interest for decades, but only recently have candidate genes started to be identified. We have performed linkage analysis and genome-wide association for height in approximately 4000 individuals from five European populations. A total of five chromosomal regions showed suggestive linkage and in one of these regions, two SNPs (rs849140 and rs1635852) were associated with height (nominal P = 7.0 x 10(-8) and P = 9.6 x 10(-7), respectively). In total, five SNPs across the genome showed an association with height that reached the threshold of genome-wide significance (nominal P < 1.6 x 10(-7)). The association with height was replicated for two SNPs (rs1635852 and rs849140) using three independent studies (n = 31 077, n=1268 and n = 5746) with overall meta P-values of 9.4 x 10(-10) and 5.3 x 10(-8). These SNPs are located in the JAZF1 gene, which has recently been associated with type II diabetes, prostate and endometrial cancer. JAZF1 is a transcriptional repressor of NR2C2, which results in low IGF1 serum concentrations, perinatal and early postnatal hypoglycemia and growth retardation when knocked out in mice. Both the linkage and association analyses independently identified the JAZF1 region affecting human height. We have demonstrated, through replication in additional independent populations, the consistency of the effect of the JAZF1 SNPs on height. Since this gene also has a key function in the metabolism of growth, JAZF1 represents one of the strongest candidates influencing human height identified so far.

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Scopus
Cited By

Altmetric

7.249

2.350