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The CALM and CALM/AF10 interactor CATS is a marker for proliferation.
Mol. Oncol. 2, 356-367 (2008)
The CATS protein was recently identified as a novel CALM interacting protein. CATS increases the nuclear and specifically the nucleolar localization of the leukemogenic CALM/AF10 fusion protein. We cloned and characterized the murine Cats gene. Detailed analysis of murine Cats expression during mouse embryogenesis showed an association with rapidly proliferating tissues. Interestingly, the Cats transcript is highly expressed in murine hematopoietic cells transformed by CALM/AF10. The CATS protein is highly expressed in leukemia, lymphoma and tumor cell lines but not in non-proliferating T-cells or human peripheral blood lymphocytes. CATS protein levels are cell cycle dependent and it is induced by mitogens, suggesting a role of CATS in the control of cell proliferation and possibly CALM/AF10-mediated leukemogenesis.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
0.200
0.000
7
27
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
CALM/AF10; Leukemia; Nucleolus; Proliferation; CATS
Sprache
englisch
Veröffentlichungsjahr
2008
HGF-Berichtsjahr
2008
ISSN (print) / ISBN
1574-7891
e-ISSN
1878-0261
Zeitschrift
Molecular Oncology
Quellenangaben
Band: 2,
Heft: 4,
Seiten: 356-367
Verlag
Elsevier
Verlagsort
Amsterdam [u.a.]
Begutachtungsstatus
Peer reviewed
Institut(e)
CCG Pathogenesis of Acute Myeloid Leukemia (KKG-KPL)
Institute of Molecular Immunology (IMI)
Institute of Experimental Genetics (IEG)
Institute of Molecular Immunology (IMI)
Institute of Experimental Genetics (IEG)
POF Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30201 - Metabolic Health
30201 - Metabolic Health
Forschungsfeld(er)
Immune Response and Infection
Genetics and Epidemiology
Genetics and Epidemiology
PSP-Element(e)
G-521000-001
G-501700-003
G-500600-003
G-501700-003
G-500600-003
Scopus ID
56349104437
Erfassungsdatum
2008-12-08