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The CALM and CALM/AF10 interactor CATS is a marker for proliferation.

Mol. Oncol. 2, 356-367 (2008)
DOI
Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.
The CATS protein was recently identified as a novel CALM interacting protein. CATS increases the nuclear and specifically the nucleolar localization of the leukemogenic CALM/AF10 fusion protein. We cloned and characterized the murine Cats gene. Detailed analysis of murine Cats expression during mouse embryogenesis showed an association with rapidly proliferating tissues. Interestingly, the Cats transcript is highly expressed in murine hematopoietic cells transformed by CALM/AF10. The CATS protein is highly expressed in leukemia, lymphoma and tumor cell lines but not in non-proliferating T-cells or human peripheral blood lymphocytes. CATS protein levels are cell cycle dependent and it is induced by mitogens, suggesting a role of CATS in the control of cell proliferation and possibly CALM/AF10-mediated leukemogenesis.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter CALM/AF10; Leukemia; Nucleolus; Proliferation; CATS
Sprache englisch
Veröffentlichungsjahr 2008
HGF-Berichtsjahr 2008
ISSN (print) / ISBN 1574-7891
e-ISSN 1878-0261
Zeitschrift Molecular Oncology
Quellenangaben Band: 2, Heft: 4, Seiten: 356-367 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam [u.a.]
Begutachtungsstatus Peer reviewed
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease

30201 - Metabolic Health
Forschungsfeld(er) Immune Response and Infection

Genetics and Epidemiology
PSP-Element(e) G-521000-001
G-501700-003
G-500600-003
Scopus ID 56349104437
Erfassungsdatum 2008-12-08