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Relationship of body weight to disposition of hexachlorobenzene in rats.

Toxicol. Lett. 18, 171-175 (1983)
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Male rats of various body weights were dosed twice with [14C]hexachlorobenzene (50 mg/kg, p.o.) in olive oil by gavage on 2 consecutive days. During 2 weeks after dosage, cumulative excretion into urine was about 1% of the dose and unrelated to body weight. Cumulative excretion into feces was 30 ± 10% of the dose and decreased with increasing body weight. In contrast, the concentration of hexachlorobenzene in urine, feces, kidney, liver and adipose tissue 14 days after dosing was higher in larger than in smaller animals. However, the relative concentration, i.e. the concentration of hexachlorobenzene in urine, feces or tissue divided by the concentration of hexachlorobenzene in adipose tissue, eliminated most of the variability among individual animals. This allows direct comparison of dispositional data of animals with greatly differing body burdens.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 1983
HGF-Berichtsjahr 0
ISSN (print) / ISBN 0378-4274
e-ISSN 1879-3169
Zeitschrift Toxicology Letters
Quellenangaben Band: 18, Heft: 1-2, Seiten: 171-175 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam
Begutachtungsstatus Peer reviewed
Scopus ID 0020555346
Erfassungsdatum 1983-12-31