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Haupt, C. ; Huber, A.B.

How axons see their way - axonal guidance in the visual system.

Front. Biosci. 13, 3136-3149 (2008)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
In humans up to 80% of the information received from the outside world is processed by the visual pathway. Therefore, understanding the molecular and cellular bases of the formation of the retinofugal projection has been in the focus of research during the last decades. Besides our interest in the development of the visual pathway per se this circuit is also an excellent model system to study axon guidance, midline crossing, and formation of topographic neuronal maps in general. The generation of genetic animal models as well as the design of in vitro loss- and gain-of-function paradigms have provided insight into transcriptional networks, identified signalling molecules, extracellular matrix components, morphogens, and activity patterns which are involved in the establishment of the visual pathway. To provide a picture as complete as possible, we will summarize molecular mechanisms involved in axon guidance and retinotopic mapping as well as neuronal activity shaping retinal and thalamocortical projections focusing on the mouse as a model system and highlight discoveries made in other organisms that contribute to our understanding.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter axonal guidance; visual pathway; neuronal activity; retinopic mapping; midline crossing; transcriptional networks; review
Sprache englisch
Veröffentlichungsjahr 2008
HGF-Berichtsjahr 2008
ISSN (print) / ISBN 1093-9946
e-ISSN 1093-4715
Zeitschrift Frontiers in Bioscience
Quellenangaben Band: 13, Heft: 8, Seiten: 3136-3149 Artikelnummer: , Supplement: ,
Verlag Frontiers
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Developmental Genetics (IDG)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-550400-001
DOI 10.2741/2915
Scopus ID 38449086753
Erfassungsdatum 2008-10-27
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