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Maier, K.L. ; Alessandrini, F. ; Beck-Speier, I. ; Hofer, T.P. ; Diabaté, S.* ; Bitterle, E.* ; Stöger, T. ; Jakob, T.* ; Behrendt, H. ; Horsch, M. ; Beckers, J. ; Ziesenis, A.* ; Hültner, L. ; Frankenberger, M. ; Krauss-Etschmann, S. ; Schulz, S.

Health effects of ambient particulate matter - biological mechanisms and inflammatory responses to in vitro and in vivo particle exposures.

Inhal. Toxicol. 20, 319-337 (2008)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
In this article, we review and analyze different modes of exposure to ultrafine particles in order to assess particle-induced inflammatory responses and the underlying mechanisms in vitro and in vivo. Based on results from monocytic cells cultured under submerged conditions, we discuss (1) the impact of particle properties such as surface area and oxidative potential on lipid metabolism as a highly sensitive regulatory pathway and (2) the interference of diesel exhaust particles with toll-like receptor-mediated inflammatory responses. Furthermore, new developments of air-liquid interface exposure used as an alternative approach to simulate cell particle interactions are presented. In addition to the in vitro approaches, animal exposure studies are described that apply selected mouse models to elucidate potential allergic and inflammatory pulmonary responses and mast-cell-related mechanisms after particle exposure. Long-term inhalation of ultrafine particles might lead to irreversible changes in lung structure and function. Clinical studies addressing the characteristics of inflammatory airway cells are a promising approach to understand underlying pathophysiological mechanisms in chronic obstructive pulmonary disease. Finally, a potential outcome of human particle exposure is chronic cough in children. Here, discrimination between asthmatic and nonasthmatic cough by means of immunological parameters appears to be an important step toward improving diagnosis and therapy.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2008
HGF-Berichtsjahr 0
ISSN (print) / ISBN 0895-8378
e-ISSN 1091-7691
Zeitschrift Inhalation Toxicology
Quellenangaben Band: 20, Heft: 3, Seiten: 319-337 Artikelnummer: , Supplement: ,
Verlag Informa Healthcare
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Experimental Genetics (IEG)
Institute of Clinical Molecular Biology and Tumor Genetics (K.MOLBI)
Institute of Lung Health and Immunity (LHI)
Institute of Epidemiology (EPI)
CCG Tumor Therapy with Hyperthermia (IMI-KTH)
POF Topic(s) 30201 - Metabolic Health
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
Immune Response and Infection
PSP-Element(e) G-500600-004
G-501400-005
G-521200-001
FE 73991
G-520200-001
G-521100-001
PubMed ID 18300050
DOI 10.1080/08958370701866313
WOS ID 000254821900008
Erfassungsdatum 2008-04-01
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