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Pinto, L. ; Götz, M.

Radial glial cell heterogeneity--the source of diverse progeny in the CNS.

Prog. Neurobiol. 83, 2-23 (2007)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Here, we discuss the identity, heterogeneity and functions of radial glial cells mostly in the developing central nervous system (CNS). First, we define radial glial cells by morphological, cell biological and molecular criteria as true glial cells, akin to astroglia. We then describe the appearance of radial glial cells during neural development as a precursor intermediate between immature neuroepithelial cells and differentiating progeny. Then we review the diverse progeny arising in different lineages from radial glial cells as observed by clonal analyses and time-lapse imaging. This leads us to discuss the molecular mechanisms involved in the regulation of the lineage heterogeneity of radial glial cells - including their diversity in distinct regions of the CNS. We conclude by considering the possible mechanisms allowing neurogenic radial glial cells to persist into adulthood in various vertebrate classes ranging from fish to birds, while neurogenic glial cells become restricted to few small regions of the adult forebrain in mice and men.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Neurogenesis; Pax6; Regeneration; Neural stem cells; Patterning; Basal precursors; Apico-basal polarity; Basement membrane; Astroglia; Muller glia; Bergmann glia
Sprache englisch
Veröffentlichungsjahr 2007
HGF-Berichtsjahr 2007
ISSN (print) / ISBN 0301-0082
e-ISSN 1873-5118
Zeitschrift Progress in Neurobiology
Quellenangaben Band: 83, Heft: 1, Seiten: 2-23 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Stem Cell Research (ISF)
POF Topic(s) 30204 - Cell Programming and Repair
Forschungsfeld(er) Stem Cell and Neuroscience
PSP-Element(e) G-500800-001
PubMed ID 1758010
DOI 10.1016/j.pneurobio.2007.02.010
WOS ID 000249544800002
Scopus ID 34547812737
Erfassungsdatum 2007-09-29
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